Head of Laboratory for Proteomics of Supraorganismal Systems at ARRIAM, Acting Head of Department of Genetics and Biotechnology at SPbSU, Editor-in-Chief of the “Biological Communications” Journal
Информация
CURRENT POSITIONS:
Head of Laboratory for Proteomics of Supraorganismal Systems at ARRIAM
https://arriam.ru/departments/laboratoriya-proteomiki-nadorganizmennyh-sistem/
Acting Head of Department of Genetics and Biotechnology at SPbSU
https://bio.spbu.ru/faculty/departments/genetics/
Editor-in-Chief of the “Biological Communications” Journal
https://biocomm.spbu.ru/
SCIENTIFIC INTERESTS: Protein structure, protein-protein interactions, amyloids, prions, plant-microbial interactions, mechanisms of virulence of prokaryotes, symbiosis, yeast genetics, bacterial genetics, plant genetics, translation, computational biology, structural and functional proteomics, bioinformatics, genomics , transcriptomics, systems biology, chromatography, mass spectrometry, history of biology.
IDs: Google Scholar, PubMed, Scopus, Researcher ID
RECENT PUBLICATIONS:
- Shikov A.E., Malovichko Yu.V., Lobov A.A., Belousova M.E., Nizhnikov A.A., Antonets K.S. The distribution of several genomic virulence determinants does not corroborate the established serotyping classification of Bacillus thuringiensis // International Journal of Molecular Sciences, 2021, V.22, e2244.
- Yuzikhin O.S., Gogoleva N.E., Shaposhnikov A.I., Konnova T.A., Osipova E.V., Syrova D.S., Ermakova E.A., Shevchenko V.P., Nagaev I.Yu., Shevchenko K.V., Myasoedov N.F., Safronova V.I., Shavarda A.L., Nizhnikov A.A., Belimov A.A., Gogolev Yu.V. Rhizosphere bacterium Rhodococcus sp. P1Y metabolizes abscisic acid to form dehydrovomifoliol // Biomolecules, 2021, V.11, e345.
- Evdokimova O.L., Belousova M.E., Evdokimova A.V., Kusova T.V.,. Baranchikov A.E, Antonets K.S., Nizhnikov A.A., Agafonov A.V. Fast and simple approach for production of antibacterial nanocellulose/cuprous oxide hybrid films // Cellulose, 2021, V.28.
- Kosolapova A.O., Antonets K.S., Belousov M.V., Nizhnikov A.A. Biological functions of prokaryotic amyloids in the interspecies interactions: facts and assumptions // International Journal of Molecular Sciences, 2020, V.21, e7240.
- Antonets K.S., Belousov M.V., Sulatskaya A.I., Belousova M.E., Kosolapova A.O., Sulatsky M.I., Andreeva E.A., Zykin P.A., Malovichko Y.V., Shtark O.Y., Lykholay A.N., Volkov K.V., Kuznetsova I.M., Turoverov K.K., Kochetkova E.Y., Bobylev A.G., Usachev K.S., Demidov O.N., Tikhonovich I.A., Nizhnikov A.A. Accumulation of storage proteins in plant seeds is mediated by amyloid formation // PLOS Biology, 2020, V.18(7), e3000564. https://doi.org/10.1371/journal.pbio.3000564.
- Malovichko Y.V., Shtark O.Y., Vasileva E.N., Nizhnikov A.A., Antonets K.S. Transcriptomic insights into mechanisms of early seed maturation in garden pea (Pisum sativum L.) // Cells, 2020, V.9, e779.
- Shikov A.E., Malovichko Y.V., Skitchenko R.K., Nizhnikov A.A., Antonets K.S. No more tears: mining sequencing data for novel Bt Cry toxins with CryProcessor // Toxins, 2020, V.12, e204.
- Kosolapova A.O., Belousov M.V., Sulatskaya A.I., Belousova M.E., Sulatsky M.I., Antonets K.S., Volkov K.V., Lykholay A.N., Shtark O.Y., Vasilieva E.N., Zhukov V.A., Ivanova A.N., Zykin P.A., Kuznetsova I.M., Turoverov K.K., Tikhonovich I.A., Nizhnikov A.A. Two Novel Amyloid Proteins, RopA and RopB, from the Root Nodule Bacterium Rhizobium leguminosarum // Biomolecules, 2019, V.9, e694.
- Sopova J.V., Koshel E.I., Belashova T.A., Zadorsky S.P., Sergeeva A.V., Siniukova V.A., Shenfeld A.A., Velizhanina M.E., Volkov K.V., Nizhnikov A.A., Kachkin D.V., Gaginskaya E.R., Galkin A.P., 2019. RNA-binding protein FXR1 is presented in rat brain in amyloid form // Scientific Reports, V.9, e18983.
- Malovichko Y.V., Nizhnikov A.A., Antonets K.S. Repertoire of the Bacillus thuringiensis virulence factors unrelated to major classes of protein toxins and its role in specificity of host-pathogen interactions // Toxins, 2019, e11060347.
- Malovichko Y.V., Antonets K.S., Maslova A.R., Andreeva E.A., Inge-Vechtomov S.G., Nizhnikov A.A. RNA Sequencing reveals specific transcriptomic signatures distinguishing effects of the [SWI+] prion and SWI1 deletion in yeast Saccharomyces cerevisiae // Genes, 2019, V.10, e212.
- Antonets K.S., Kliver S.F., Nizhnikov A.A. Exploring proteins containing amyloidogenic regions in the proteomes of bacteria of the order Rhizobiales // Evolutionary Bioinformatics, 2018, V.14, P.1-12.
- Belousov M.V., Bondarev S.A., Kosolapova A.O., Antonets K.S., Sulatskaya A.I., Sulatsky M.I., Zhouravleva G.A., Kuznetsova I.M., Turoverov K.K., Nizhnikov A.A. M60-like metalloprotease domain of the Escherichia coli YghJ protein forms amyloid fibrils // PLOS One, 2018, V.13(1), e0191317.
- Ryzhova T.A., Sopova J.V., Zadorsky S.P., Siniukova V.A., Sergeeva A.V., Galkina S.A., Nizhnikov A.A., Shenfeld A.A., Volkov K.V., Galkin A.P. Screening for amyloid proteins in the yeast proteome // Current Genetics, 2018, V.64, P.469-478.
- Antonets K.S., Nizhnikov A.A. Predicting amyloidogenic proteins in the proteomes of plants // International Journal of Molecular Sciences, 2017, V.18, e2155.
- Antonets K.S., Nizhnikov A.A. Amyloids and prions in plants: facts and perspectives // Prion, 2017, V.11, P.300-312.
- Matveenko A.G., Drozdova P.B., Belousov M.V., Moskalenko S.E., Bondarev S.A., Barbitoff Y.A., Nizhnikov A.A., Zhouravleva G.A. SFP1-mediated prion-dependent lethality is caused by increased Sup35 aggregation and alleviated by Sis1 // Genes to Cells, 2016, V.21, P.1290–1308.
- Nizhnikov А.А., Ryzhova T.А., Volkov K.V., Zadorsky S.P., Sopova J.V., Inge-Vechtomov S.G., Galkin A.P. Interaction of prions causes heritable traits in Saccharomyces cerevisiae // PLOS Genetics, 2016, V.12, e1006504.
- Nizhnikov A.A., Antonets K.S., Bondarev S.A., Inge-Vechtomov S.G., Derkatch I.L. Prions, Amyloids, and RNA: Pieces of a Puzzle // Prion, 2016, V.10, P.1-25.
- Nizhnikov A.A., Alexandrov A.I., Ryzhova T.A., Mitkevich O.V., Dergalev A.A., Ter-Avanesyan M.D., Galkin A.P. Proteomic Screening for Amyloid Proteins // PLOS One, 2014, V.9(12), e116003.
- Nizhnikov A.A., Antonets K.S, Inge-Vechtomov S.G., Derkatch I.L. Modulation of efficiency of translation termination in Saccharomyces cerevisiae: turning nonsense into sense // Prion, 2014, V.8, P.247-260.
- Antonets K.S., Nizhnikov A.A. SARP: a novel algorithm to assess compositional biases in protein sequences // Evolutionary Bioinformatics, 2013, V.9, P.263-273.
- Nizhnikov A.A., Magomedova Z.M., Rubel A.A., Kondrashkina A.M., Inge-Vechtomov S.G., Galkin A.P. [NSI+] determinant has a pleiotropic phenotypic manifestation that is modulated by SUP35, SUP45, and VTS1 genes // Current Genetics, 2012, V.58, P.35-47.
- Saifitdinova A.F., Nizhnikov A.A., Lada A.G., Rubel A.A., Magomedova Z.M., Ignatova V.V., Inge-Vechtomov S.G., Galkin A.P. [NSI+]: a novel non-Mendelian nonsense suppressor determinant in Saccharomyces cerevisiae // Current Genetics, 2010, V.56, P.467-478.
RECENT GRANTS:
- Grant of the Russian Science Foundation 17-16-01100 “Proteomic screening of amyloid proteins in pea (Pisum sativum L.) and root nodule bacterium (Rhizobium leguminosarum)”, 2017-2019, Principal investigator.
- Grant of the Russian Foundation for Basic Research 20-316-70020 “Dissection of interrelations between proteomic landscapes of Bacillus thuringiensis, its serovar and life cycle stages”; 2019-2021, Principal investigator.
- Grant of the President of the Russian Federation for state support of young scientists, MK-3240.2017.4 "Study of the role of amyloidogenesis in the pathogenicity of bacteria of the Enterobacteriaceae family”; 2017-2018, Principal investigator.
- Grant of the President of the Russian Federation for state support of young scientists, MK-4854.2015.4 "Proteomic screening of proteins that form amyloids in bacteria Escherichia coli”; 2015-2016, Principal investigator.
- Grant of the Russian Foundation for Basic Research 16-34-60153 «Identification of new prions, amyloids, and fators affecting the protein's ability to prionization and the formation of amyloid structure"; 2016-2018, Principal investigator.
